Erlotinib-13C6(Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

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Erlotinib-13C6 (Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

Erlotinib-13C6 (CP-358774-13C6) 是一种 13C 标记的 Erlotinib。Erlotinib 是一种直接作用的 EGFR 酪氨酸激酶抑制剂，对人 EGFR 的 IC50 为 2 nM。

Erlotinib-13C6(Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

Erlotinib-13C6 Chemical Structure

CAS No. : 1211107-68-4

规格 价格 是否有货
1 mg ￥15500 询问价格 & 货期

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生物活性

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

体外研究
(In Vitro)

Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

399.39

Formula

C1613C6H23N3O4
CAS 号

1211107-68-4
中文名称

埃罗替尼 13C6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848.

    [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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