QM31(Synonyms: SVT016426)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

QM31 (Synonyms: SVT016426)

QM31 (SVT016426) 是一种细胞保护剂，是 Apaf-1 的选择性抑制剂。QM31 抑制凋亡体的形成 (IC50=7.9 μM)，凋亡体是由 Apaf-1、细胞色素 c、dATP 和 caspase-9 组成的 caspase 激活复合物。QM31 具有线粒体保护功能，干扰 S 期 DNA 损伤检测点。

QM31(Synonyms: SVT016426)

QM31 Chemical Structure

CAS No. : 937735-00-7

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生物活性

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].

体外研究
(In Vitro)

SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC50 of 5 μM in HeLa S100 cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

768.56

Formula

C39H38Cl4N4O4
CAS 号

937735-00-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90.

    [2]. Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979.

    [3]. Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43.

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