7-xylosyltaxol(Synonyms: 7-Xylosylpaclitaxel; Taxol-7-xyloside)

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7-xylosyltaxol (Synonyms: 7-Xylosylpaclitaxel; Taxol-7-xyloside)

7-xylosyltaxol(Taxol-7-xyloside)是紫杉醇衍生物。

7-xylosyltaxol(Synonyms: 7-Xylosylpaclitaxel;  Taxol-7-xyloside)

7-xylosyltaxol Chemical Structure

CAS No. : 90332-66-4

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生物活性

7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules. IC50 Value: Target: Microtubule/Tubulin Paclitaxel is a compound extracted from the Pacific yew tree with antineoplastic activity. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). Paclitaxel inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Paclitaxel induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.

分子量

986.02

Formula

C52H59NO18

CAS 号

90332-66-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yu SS, Sun QW, Zhang XP, et al. Content and distribution of active components in cultivated and wild Taxus chinensis var. mairei plants. Ying Yong Sheng Tai Xue Bao. 2012 Oct;23(10):2641-7.

    [2]. Chao Z, Tan M, Paudel MK, et al. Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel. J Nat Med. 2012 Sep 25.

    [3]. Park SJ, Wu CH, Gordon JD, et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3;279(49):51057-67. Epub 2004 Sep 27.

    [4]. Rao S, He L, Chakravarty S, et al. Characterization of the Taxol binding site on the microtubule. Identification of Arg(282) in beta-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol. J Biol Chem. 1999 Dec 31;274(53):37990-4.

    [5]. Paclitaxel

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