PD-1/PD-L1-IN-27

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PD-1/PD-L1-IN-27 

PD-1/PD-L1-IN-27 是一种有效的 PD-1/PD-L1 抑制剂,IC50 值为 134 nM。 PD-1/PD-L1-IN-27 具有低 T 细胞毒性的抗肿瘤作用。PD-1/PD-L1-IN-27 具有激活 CD8+ T 细胞和减少 T 细胞耗竭的能力。

PD-1/PD-L1-IN-27

PD-1/PD-L1-IN-27 Chemical Structure

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生物活性

PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].

IC50 & Target

IC50: 134 nM (PD-1/PD-L1)[1]

体外研究
(In Vitro)

PD-1/PD-L1-IN-27 (compound MZ58) (2.5, 5, 10, 50 µM; 48 h) shows antitumor effects with low T cell cytotoxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 50 µM
Incubation Time: 48 h
Result: Facilitated cell proliferation with low T cell cytotoxicity.

体内研究
(In Vivo)

PD-1/PD-L1-IN-27 (10, 25 mg/kg; i.g.) shows antitumor effecct[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-22 g, 6-8 weeks, male C57BL/6J mice (MC 38 cell lines)[1]
Dosage: 10, 25 mg/kg
Administration: I.g.
Result: Showed antitumor effecct.

分子量

673.75

Formula

C44H35NO6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhang M, et al. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022; 54:116579.

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