PD-1/PD-L1-IN-27

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PD-1/PD-L1-IN-27 

PD-1/PD-L1-IN-27 是一种有效的 PD-1/PD-L1 抑制剂，IC50 值为 134 nM。 PD-1/PD-L1-IN-27 具有低 T 细胞毒性的抗肿瘤作用。PD-1/PD-L1-IN-27 具有激活 CD8+ T 细胞和减少 T 细胞耗竭的能力。

PD-1/PD-L1-IN-27

PD-1/PD-L1-IN-27 Chemical Structure

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生物活性

PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].

IC50 & Target

IC50: 134 nM (PD-1/PD-L1)[1]
体外研究
(In Vitro)

PD-1/PD-L1-IN-27 (compound MZ58) (2.5, 5, 10, 50 µM; 48 h) shows antitumor effects with low T cell cytotoxicity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10, 50 µM
Incubation Time: 48 h
Result: Facilitated cell proliferation with low T cell cytotoxicity.

体内研究
(In Vivo)

PD-1/PD-L1-IN-27 (10, 25 mg/kg; i.g.) shows antitumor effecct[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-22 g, 6-8 weeks, male C57BL/6J mice (MC 38 cell lines)[1]
Dosage: 10, 25 mg/kg
Administration: I.g.
Result: Showed antitumor effecct.

分子量

673.75

Formula

C44H35NO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang M, et al. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022; 54:116579.

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