OM-153

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

OM-153 

OM-153 是一种有效的 tankyrase 抑制剂，对 tankyrase 1 和 tankyrase 2 的 IC50 分别为 13 和 2 nM。OM-153 抑制 COLO 320DM 中的 WNT/β-连环蛋白信号传导和增殖。

OM-153

OM-153 Chemical Structure

CAS No. : 2406278-81-5

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生物活性

OM-153 is a potent tankyrase inhibitor with IC50s of 13 and 2 nM for tankyrase 1 and tankyrase 2, respectively. OM-153 shows inhibition of WNT/β-catenin signaling and proliferation in COLO 320DM[1].

IC50 & Target[1]

TNKS1

13 nM (IC50)

TNKS2

2 nM (IC50)

体外研究
(In Vitro)

OM-153 shows picomolar IC50 inhibition (0.63 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay, no off-target liabilities, overall favorable absorption, distribution, metabolism, and excretion (ADME) properties, and an improved pharmacokinetic profile in mice[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

509.53

Formula

C28H24FN7O2
CAS 号

2406278-81-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

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