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GLL398
GLL398 是一种具有口服活性选择性雌激素受体降解剂 (SERD)，与雌激素受体竞争性结合，IC50 值为 1.14 nM。GLL398 对具有 Y537S 点突变 (IC50= 29.5 nM) 的 ER 表现出强烈的剂量依赖性结合。GLL398 在异种乳腺癌模型中阻断肿瘤生长。
GLL398 Chemical Structure
CAS No. : 2077980-80-2
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1]. |
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| 体外研究 (In Vitro) |
GLL398 is a boron-modified GW5638 analog[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
398.26 |
| Formula |
C25H23BO4 |
| CAS 号 |
2077980-80-2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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