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AMTB hydrochloride 纯度: 99.41%
AMTB hydrochloride 是一种选择性 TRPM8 通道阻滞剂。AMTB hydrochloride 抑制 icilin诱导的 TRPM8 通道激活,pIC50 为 6.23。AMTB hydrochloride 可用于膀胱过度活动和膀胱疼痛综合征的研究。AMTB hydrochloride 是电压门控钠通道的非选择性抑制剂 (NaV)。
AMTB hydrochloride Chemical Structure
CAS No. : 926023-82-7
规格 | 价格 | 是否有货 | 数量 |
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5 mg | ¥900 | In-stock | |
10 mg | ¥1600 | In-stock | |
25 mg | ¥3400 | In-stock | |
50 mg | ¥5700 | In-stock | |
100 mg | ¥9500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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AMTB hydrochloride 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Membrane Transporter/Ion Channel Compound Library
- Neuronal Signaling Compound Library
- Anti-Cancer Compound Library
- Anti-Breast Cancer Compound Library
- Mechanoreceptors Compound Library
生物活性 |
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV)[1][2]. |
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体外研究 (In Vitro) |
AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8)[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
430.99 |
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Formula |
C23H27ClN2O2S |
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CAS 号 |
926023-82-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (232.02 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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