Mycophenolate mofetil hydrochloride(Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride)

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Mycophenolate mofetil hydrochloride (Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride)

Mycophenolate Mofetil (RS 61443) hydrochloride 是非竞争性可逆的次黄嘌呤核苷单磷酸脱氢酶 (IMPDH) I/II 抑制剂，免疫抑制剂，IC50分别为39 nM 和 27 nM。

Mycophenolate mofetil hydrochloride(Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride)

Mycophenolate mofetil hydrochloride Chemical Structure

CAS No. : 116680-01-4

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Mycophenolate mofetil hydrochloride 的其他形式现货产品:

Mycophenolate Mofetil

生物活性

Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC50s of 39 nM and 27 nM, respectively.

IC50 & Target

Human Endogenous Metabolite

 

分子量

469.96

Formula

C23H32ClNO7
CAS 号

116680-01-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nakanishi, T., et al., Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol, 2010. 10(1): p. 91-7.

    [2]. Dehghani, F., et al., Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil. Neuropathol Appl Neurobiol, 2010. 36(7): p. 598-611.

    [3]. Ozgen, M., et al., Mycophenolate mofetil and daclizumab targeting T lymphocytes in bleomycin-induced experimental scleroderma. Clin Exp Dermatol, 2012. 37(1): p. 48-54.

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