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Ziftomenib (Synonyms: KO-539)
Ziftomenib (KO-539) 是一种 menin-MLL 相互作用的抑制剂，具有抗肿瘤活性 (WO2017161028A1, compound 151)。
Ziftomenib Chemical Structure
CAS No. : 2134675-36-6
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥22000 | 询问价格 & 货期 | |
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| 生物活性 |
Ziftomenib (KO-539) is a menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151)[1]. |
|---|---|
| 体外研究 (In Vitro) |
The mixed-lineage leukemia (MLL) protein is a histone methyltransferase critical for the epigenetic regulation of gene transcription. Many acute leukemias, including acute myeloblastic leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed-lineage leukemia (MLL), are characterized by the presence of chimeric MLL fusion proteins that result from chromosomal translocations of the MLL gene located at chromosome 11, band q23 (11q23). MLL fusion proteins lack the original histone methyltransferase activity of the C-terminus of MLL and gain the ability to regulate transcription of numerous oncogenes, including HOX and MEIS1, resulting in increased cell proliferation and decreased cell differentiation, ultimately leading to leukemogenesis[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
717.87 |
| Formula |
C33H42F3N9O2S2 |
| CAS 号 |
2134675-36-6 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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