Poly-D-lysine hydrobromide (MW 30000-70000)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Poly-D-lysine hydrobromide (MW 30000-70000) 

Poly-D-lysine hydrobromide (MW 30000-70000) 是一种人工合成的高分子基质,是神经细胞培养应用最广泛的基质之一。Poly-D-lysine hydrobromide (MW 30000-70000) 可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP,而不影响PrPC

Poly-D-lysine hydrobromide (MW 30000-70000)

Poly-D-lysine hydrobromide (MW 30000-70000) Chemical Structure

CAS No. : 27964-99-4

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生物活性

Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].

体外研究
(In Vitro)

Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1].
The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

30000-70000

Formula

(C6H14N2O2)x.xHBr

CAS 号

27964-99-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229.

    [2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35.

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