Avasopasem manganese(Synonyms: GC-4419; M-40419)

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Avasopasem manganese (Synonyms: GC-4419; M-40419)

Avasopasem manganese (GC4419;M-40419) 是一种有效的超氧化物歧化酶,能迅速和特异性地将 O2*- 转化为过氧化氢 (H2O2),阻止这一级联反应的启动。Avasopasem manganese 可用于严重口腔黏膜炎 (SOM) 和癌症的研究。

Avasopasem manganese(Synonyms: GC-4419;  M-40419)

Avasopasem manganese Chemical Structure

CAS No. : 435327-40-5

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生物活性

Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].

体内研究
(In Vivo)

Avasopasem manganese is an agent intended to interrupt severe oral mucositis pathogenesis, to reduce the duration, incidence, and severity of radiation-induced oral mucositis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

479.35

Formula

C21H31Cl2MnN5

CAS 号

435327-40-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265.

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