Thalidomide-O-amido-C6-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 11; E3 Ligase Ligand-Linker Conjugates 25)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Thalidomide-O-amido-C6-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 11; E3 Ligase Ligand-Linker Conjugates 25)

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Thalidomide 的 cereblon 配体和 1 个 linker。可用于合成 PROTAC 分子。

Thalidomide-O-amido-C6-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 11;  E3 Ligase Ligand-Linker Conjugates 25)

Thalidomide-O-amido-C6-NH2 Chemical Structure

CAS No. : 1950635-13-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Thalidomide-O-amido-C6-NH2 的其他形式现货产品:

Thalidomide-O-amido-C6-NH2 TFA

生物活性

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

430.45

Formula

C21H26N4O6

CAS 号

1950635-13-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bradner J, et al. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses. WO 2017024318 A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务