Venadaparib hydrochloride(Synonyms: IDX-1197 hydrochloride)

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Venadaparib hydrochloride (Synonyms: IDX-1197 hydrochloride)

Venadaparib (IDX-1197) hydrochloride 是一种有效的选择性 PARP 抑制剂,具有抗癌活性。Venadaparib hydrochloride 可用于实体瘤研究。

Venadaparib hydrochloride(Synonyms: IDX-1197 hydrochloride)

Venadaparib hydrochloride Chemical Structure

CAS No. : 1681020-60-9

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生物活性

Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].

IC50 & Target[1]

PARP1

1.4 nM (IC50)

PARP2

1 nM (IC50)

体外研究
(In Vitro)

Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC50 values of ≤5nM and 50nM [2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

442.91

Formula

C23H24ClFN4O2

CAS 号

1681020-60-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yong Man Kim, et al. First-in-human dose-finding study of venadaparib (IDX-1197), a potent and selective PARP inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology. 39, no. 15_suppl (May 20, 2021) 3107-3107.

    [2]. Jae-Hoon Kang, et al. A novel phtalazinone derivatives and manufacturing process thereof. WO2015037939A1.

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