Thalidomide-O-amido-PEG2-C2-NH2(Synonyms: Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Thalidomide-O-amido-PEG2-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24)

Thalidomide-O-amido-PEG2-C2-NH2 结合了E3连接酶配体和 linker,可作为免疫调节剂治疗癌症。

Thalidomide-O-amido-PEG2-C2-NH2(Synonyms: Cereblon  Ligand-Linker Conjugates 10;  E3 Ligase Ligand-Linker Conjugates 24)

Thalidomide-O-amido-PEG2-C2-NH2 Chemical Structure

CAS No. : 1957235-74-3

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Thalidomide-O-amido-PEG2-C2-NH2 的其他形式现货产品:

Thalidomide-O-amido-PEG2-C2-NH2 TFA

生物活性

Thalidomide-O-amido-PEG2-C2-NH2 incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer.

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

462.45

Formula

C21H26N4O8

CAS 号

1957235-74-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.

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