Amifostine trihydrate(Synonyms: WR2721 trihydrate)

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Amifostine trihydrate (Synonyms: WR2721 trihydrate)

Amifostine trihydrate (WR2721 trihydrate) 是一种广谱细胞保护剂和辐射防护剂。Amifostine trihydrate 可选择性保护正常组织免受放射线和化学疗法造成的损害。Amifostine trihydrate 是有效的 HIF-α1 和 p53 诱导剂。Amifostine trihydrate 通过清除氧衍生的自由基来保护细胞免受损伤。Amifostine trihydrate 可降低肾脏毒性并具有抗血管生成作用。

Amifostine trihydrate(Synonyms: WR2721 trihydrate)

Amifostine trihydrate Chemical Structure

CAS No. : 112901-68-5

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Amifostine trihydrate 的其他形式现货产品:

Amifostine

生物活性

Amifostine trihydrate (WR2721 trihydrate) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine trihydrate selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine trihydrate is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine trihydrate protects cells from damage by scavenging oxygen-derived free radicals. Amifostine trihydrate reduces renal toxicity and has antiangiogenic action[1][2][3][4].

Clinical Trial

分子量

284.27

Formula

C5H21N2O7PS
CAS 号

112901-68-5
中文名称

氨磷汀三水合物；安磷汀三水合物；阿米福汀三水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

    [2]. John R Kouvaris, et al. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist. 2007 Jun;12(6):738-47.

    [3]. D Maurici, et al. Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay. Oncogene. 2001 Jun 14;20(27):3533-40.

    [4]. Efstathia Giannopoulou, et al. Amifostine inhibits angiogenesis in vivo. J Pharmacol Exp Ther. 2003 Feb;304(2):729-37.

    [5]. Michael I Koukourakis, et al. Amifostine induces anaerobic metabolism and hypoxia-inducible factor 1 alpha. Cancer Chemother Pharmacol. 2004 Jan;53(1):8-14.

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