Tubulysin H(Synonyms: 微管蛋白抑制剂 H)

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Tubulysin H (Synonyms: 微管蛋白抑制剂 H)

Tubulysin H 是一种高度细胞毒性的肽，是从粘细菌 Archangium geophyra 和 Angiococcus disciformis 中分离的。 Tubulysin 在哺乳动物细胞中显示出极其有效的细胞毒活性，包括多药耐药细胞系，IC50 值在较低的纳摩尔范围内。 Tubulysin H 是一种具有细胞毒性活性微管溶素，抑制微管蛋白聚合并导致细胞周期停滞和凋亡。

Tubulysin H(Synonyms: 微管蛋白抑制剂 H)

Tubulysin H Chemical Structure

CAS No. : 799822-09-6

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生物活性

Tubulysin H is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. Tubulysin H is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[3].

分子量

785.99

Formula

C40H59N5O9S
CAS 号

799822-09-6
中文名称

微管蛋白抑制剂 H
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Steinmetz H, et al. Isolation, crystal and solution structure determination, and biosynthesis of tubulysins–powerful inhibitors of tubulin polymerization from myxobacteria. Angew Chem Int Ed Engl. 2004 Sep 20;43(37):4888-92.

    [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.

    [3]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.

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