Py-MPB-amino-C3-PBD

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Py-MPB-amino-C3-PBD 

Py-MPB-amino-C3-PBD 是一种细胞毒性药物，可作为 ADC 的有效载荷。具有抗微生物活性。

Py-MPB-amino-C3-PBD

Py-MPB-amino-C3-PBD Chemical Structure

CAS No. : 2412924-07-1

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生物活性

Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50 & Target

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

744.84

Formula

C41H44N8O6
CAS 号

2412924-07-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. David Edwin Thurston, et al. Polycyclic amides as cytotoxic agents. WO2020049286A1.

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