Avitinib(Synonyms: Abivertinib; AC0010)

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Avitinib (Synonyms: Abivertinib; AC0010)

Avitinib (AC0010) 是一种不可逆的、突变体选择性的 EGFR 抑制剂,可有效抑制非小细胞肺癌中EGFR T790M耐药突变。阿比替尼也是一种新型 BTK 抑制剂。

Avitinib(Synonyms: Abivertinib;  AC0010)

Avitinib Chemical Structure

CAS No. : 1557267-42-1

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Avitinib 的其他形式现货产品:

Avitinib maleate

生物活性

Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.

分子量

487.53

Formula

C26H26FN7O2

CAS 号

1557267-42-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597.

    [2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706.

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