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Malotilate (Synonyms: 马洛替酯; NKK 105) 纯度: 99.54%
Malotilate (NKK 105) 是一种口服活性的促肝药,是一种抗纤维化物质,可选择性抑制 5-lipoxygenase (5-LOX) (IC50=4.7 μM)。 Malotilate 通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中,从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
Malotilate Chemical Structure
CAS No. : 59937-28-9
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥768 | In-stock | |
10 mg | ¥698 | In-stock | |
50 mg | ¥1162 | In-stock | |
100 mg | ¥1953 | In-stock | |
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Malotilate 相关产品
•相关化合物库:
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生物活性 |
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol[5]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
288.38 |
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Formula |
C12H16O4S2 |
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CAS 号 |
59937-28-9 |
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中文名称 |
马洛替酯;二噻茂醋 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL (346.76 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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