5,6-Dichlorobenzimidazole riboside(Synonyms: DRB)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

5,6-Dichlorobenzimidazole riboside (Synonyms: DRB) 纯度: 99.87%

5,6-Dichlorobenzimidazole riboside 是一种核苷类似物，可抑制几种羧基末端结构域激酶，包括酪蛋白激酶 II 和细胞周期依赖性激酶[2]。5,6-Dichlorobenzimidazole riboside 在不诱导健康细胞遗传毒性应激的情况下，诱导人类结肠腺癌细胞的 p53 依赖性凋亡。

5,6-Dichlorobenzimidazole riboside(Synonyms: DRB)

5,6-Dichlorobenzimidazole riboside Chemical Structure

CAS No. : 53-85-0

规格 价格 是否有货 数量
25 mg ￥900 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

5,6-Dichlorobenzimidazole riboside 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Kinase Inhibitor Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Nucleotide Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

5,6-Dichlorobenzimidazole riboside is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs[1][2][3][4]. 5,6-Dichlorobenzimidazole riboside trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells[5].

分子量

319.14

Formula

C12H12Cl2N2O4
CAS 号

53-85-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMF : 100 mg/mL (313.34 mM; Need ultrasonic)

Ethanol : 7.69 mg/mL (24.10 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1334 mL 15.6671 mL 31.3342 mL
5 mM 0.6267 mL 3.1334 mL 6.2668 mL
10 mM 0.3133 mL 1.5667 mL 3.1334 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zandomeni RO. Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II. Biochem J. 1989 Sep 1;262(2):469-73.

    [2]. Yankulov K, et al. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13;270(41):23922-5.

    [3]. Rickert P, et al. Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases. Oncogene. 1999 Jan 28;18(4):1093-102.

    [4]. Schang LM. Cyclin-dependent kinases as cellular targets for antiviral drugs. J Antimicrob Chemother. 2002 Dec;50(6):779-92.

    [5]. te Poele RH, et al. RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene. 1999 Oct 14;18(42):5765-72.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务