Demethylcantharidate disodium

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Demethylcantharidate disodium  纯度: ≥98.0%

Demethylcantharidate disodium 是一种内源性代谢产物,通过内质网应激诱导肝癌细胞凋亡。Demethylcantharidate disodium 对多种类型的癌症具有良好的抗癌活性。

Demethylcantharidate disodium

Demethylcantharidate disodium Chemical Structure

CAS No. : 129-67-9

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生物活性

Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1].

体外研究
(In Vitro)

Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1].
Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCC cell lines (SMMC-7721 and Bel-7402)
Concentration: 0-100 μM
Incubation Time: 0, 12, 24, 48 or 72 hours
Result: Showed anti-proliferative activity in the two HCC cell lines.

Cell Viability Assay[1]

Cell Line: HCC cells
Concentration: 0, 9, 18 or 36 µM
Incubation Time: 24 hours
Result: Induced apoptosis in HCC cells via the intrinsic pathway.

体内研究
(In Vivo)

Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

230.13

Formula

C8H8Na2O5

CAS 号

129-67-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

参考文献
  • [1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15.

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