上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
PKI-179 纯度: ≥98.0%
PKI-179 是一种有效的和具有口服活性的双重 PI3K/mTOR 抑制剂,对 PI3K-α,PI3K-β,PI3K-γ,PI3K-δ 和 mTOR 的 IC50 值分别为 8 nM,24 nM,74 nM,77 nM 和 0.42 nM。PKI-179 还表现出对 E545K 和 H1047R 的活性,IC50 值分别为 14 nM 和 11 nM。PKI-179 在体内显示出抗肿瘤活性。
PKI-179 Chemical Structure
CAS No. : 1197160-28-3
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥2690 | In-stock | |
5 mg | ¥2500 | In-stock | |
10 mg | ¥4000 | In-stock | |
25 mg | ¥8000 | In-stock | |
50 mg | ¥12800 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
PKI-179 相关产品
•相关化合物库:
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- Clinical Compound Library Plus
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生物活性 |
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo[1][2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
PKI-179 inhibits the cell proliferation, with IC50s of 22 nM and 29 nM for MDA361 and PC3 cells, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
PKI-179 (5-50 mg/kg; p.o. once daily for 40 days) inhibits the tumor growth and is well tolerated in nude mice bearing MDA-361 human breast cancer tumors[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
488.54 |
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Formula |
C25H28N8O3 |
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CAS 号 |
1197160-28-3 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (204.69 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
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参考文献 |
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