5-Aza-7-deazaguanine

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5-Aza-7-deazaguanine  纯度: 98.06%

5-Aza-7-deazaguanine 是野生型大肠杆菌嘌呤核苷磷酸化酶 (purine nucleoside phosphorylase) 及其突变体 Ser90Ala 在碱基修饰核苷合成中的底物。

5-Aza-7-deazaguanine

5-Aza-7-deazaguanine Chemical Structure

CAS No. : 67410-64-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ¥1430 In-stock
5 mg ¥1300 In-stock
10 mg ¥2200 In-stock
25 mg ¥4500 In-stock
50 mg ¥7500 In-stock
100 mg ¥12500 In-stock
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生物活性

5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides[1].

IC50 & Target

Purine nucleoside phosphorylase, Nucleoside Antimetabolite/Analog[1]

分子量

151.13

Formula

C5H5N5O

CAS 号

67410-64-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL (33.08 mM; ultrasonic and adjust pH to 9 with NaOH)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.6168 mL 33.0841 mL 66.1682 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL
10 mM 0.6617 mL 3.3084 mL 6.6168 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Fateev IV, et al. Recognition of Artificial Nucleobases by E. coli Purine Nucleoside Phosphorylase versus its Ser90Ala Mutant in the Synthesis of Base-Modified Nucleosides. Chemistry. 2015 Sep 14;21(38):13401-19.

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