5-Methoxytryptamine(Synonyms: 5-甲氧基色胺)

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5-Methoxytryptamine (Synonyms: 5-甲氧基色胺)

5-Methoxytryptamine，一种 Melatonin 的代谢物，是一种非选择性 5-HT 受体激动剂。5-Methoxytryptamine 对 5-HT3 受体没有亲和力。5-Methoxytryptamine 也是一种有效的抗氧化剂，并具有辐射防护作用。

5-Methoxytryptamine(Synonyms: 5-甲氧基色胺)

5-Methoxytryptamine Chemical Structure

CAS No. : 608-07-1

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生物活性

5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action[1][2][3].

IC50 & Target[1][3]

Human Endogenous Metabolite

 

5-HT1 Receptor

 

5-HT2 Receptor

 

5-HT4 Receptor

 

5-HT5 Receptor

 

5-HT6 Receptor

 

5-HT7 Receptor

 

体内研究
(In Vivo)

5-Methoxytryptamine induces a significant hyperglycemia above the dosage of 1 mg/kg in rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

190.25

Formula

C11H14N2O
CAS 号

608-07-1
中文名称

5-甲氧基色胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. J Yamada, et al. Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor. Eur J Pharmacol. 1997 Apr 4;323(2-3):235-40.

    [2]. S Bayari, et al. Fourier transform infrared spectra and molecular structure of 5-methoxytryptamine, N-acetyl-5-methoxytryptamine and N-phenylsulfonamide-5-methoxytryptamine. Spectrochim Acta A Mol Biomol Spectrosc. 2003 Apr;59(6):1255-63.

    [3]. D A Craig, et al. 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):9-16.

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