VU0155069(Synonyms: CAY10593)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

VU0155069 (Synonyms: CAY10593)

VU0155069 (CAY10593)，化合物 69 是一种选择性磷脂酶 D1 (PLD1) 抑制剂，IC50 值为 46 nM。VU0155069 (CAY10593) 在 transwell 测定中强烈抑制几种癌细胞系的侵袭性迁移。

VU0155069(Synonyms: CAY10593)

VU0155069 Chemical Structure

CAS No. : 1130067-06-9

规格 是否有货
5 mg 询价

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生物活性

VU0155069 (CAY10593), compound 69, is a selective phospholipase D1 (PLD1) inhibitor with an IC50 value of 46 nM in vitro[1]. VU0155069 (CAY10593) strongly inhibits the invasive migration of several cancer cell lines in transwell assays[2].

IC50 & Target

PLD1

46 nM (IC50)

PLD2

933 nM (IC50)

分子量

462.97

Formula

C26H27ClN4O2
CAS 号

1130067-06-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Scott SA, et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009 Feb;5(2):108-17.

    [2]. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20.

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