ThrRS-IN-1

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ThrRS-IN-1 

ThrRS-IN-1 (Compound 30d) 是一种 threonyl-tRNA synthetase (ThrRS) 抑制剂，对 Salmonella enterica ThrRS (SeThrRS) 的 IC50 值为 1.4 µM，Kd 值为 1.36 µM。 ThrRS-IN-1 同时靶向 ThrRS 的 tRNAThr 和 L-threonine 结合袋。ThrRS-IN-1 具有抗细菌 (antibacterial) 活性。

ThrRS-IN-1

ThrRS-IN-1 Chemical Structure

CAS No. : 2408626-64-0

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生物活性

ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNAThr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities[1].

IC50 & Target

IC50: 1.4 µM (SeThrRS)[1]
分子量

385.25

Formula

C16H18Cl2N4O3
CAS 号

2408626-64-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Junsong Guo, et al. Discovery of novel tRNA-amino acid dual-site inhibitors against threonyl-tRNA synthetase by fragment-based target hopping. Eur J Med Chem. 2020 Feb 1;187:111941.

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