P300 bromodomain-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

P300 bromodomain-IN-1 

P300 bromodomain-IN-1 (Compoun 1u) 是一种有效的 p300 (EP300) bromodomain 抑制剂，IC50 值为 49 nM。P300 bromodomain-IN-1 抑制 c-Myc 的表达，诱导 OPM-2 细胞 G1/G0 期阻滞和凋亡 (apoptosis)。

P300 bromodomain-IN-1

P300 bromodomain-IN-1 Chemical Structure

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生物活性

P300 bromodomain-IN-1 (Compoun 1u) is a potent p300 (EP300) bromodomain inhibitor with an IC50 of 49 nM. P300 bromodomain-IN-1 suppresses the expression of c-Myc and induces G1/G0 phase arrest and apoptosis in OPM-2 cells[1].

IC50 & Target

p300

49 nM (IC50)

分子量

535.03

Formula

C29H31ClN4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen Z, et al. Discovery of novel benzimidazole derivatives as potent p300 bromodomain inhibitors with anti-proliferative activity in multiple cancer cells. Bioorg Med Chem. 2022 Jul 15;66:116784.

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