IDO1/2-IN-1 hydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

IDO1/2-IN-1 hydrochloride 

IDO1/2-IN-1 hydrochloride 是第一个有效的 IDO1/IDO2 双重抑制剂，对 IDO1 和 IDO2 的 IC50 分别为 28 nM 和 144 nM。IDO1/2-IN-1 hydrochloride 具有抗肿瘤活性。具有口服活性。

IDO1/2-IN-1 hydrochloride

IDO1/2-IN-1 hydrochloride Chemical Structure

CAS No. : 2310286-60-1

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生物活性

IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active[1].

分子量

521.73

Formula

C16H19BrClFN8O4
CAS 号

2310286-60-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.

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