HDAC6/HSP90-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HDAC6/HSP90-IN-1 

HDAC6/HSP90-IN-1 (化合物17) 是一种有效的选择性的 HDAC6 和 HSP90 的双重抑制剂，IC50 值分别为 4.3 和 46.8 nM。HDAC6/HSP90-IN-1 可下调 INF-γ 处理的 H1975 肺癌细胞中 PD-L1 的表达。HDAC6/HSP90-IN-1 在 H1975 异种移植小鼠中抑制肿瘤生长。

HDAC6/HSP90-IN-1

HDAC6/HSP90-IN-1 Chemical Structure

CAS No. : 2411955-43-4

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生物活性

HDAC6/HSP90-IN-1 (compound 17) is a potent and selective dual inhibitor of HDAC6 and HSP90, with IC50 values of 4.3 and 46.8 nM, respectively. HDAC6/HSP90-IN-1 down-regulates PD-L1 expression in INF-γ treated H1975 lung cancer cells. HDAC6/HSP90-IN-1 inhibits tumor growth in human H1975 xenograft mice[1].

IC50 & Target

HDAC6

4.32 nM (IC50)

HSP90

46.8 nM (IC50)

HDAC3

1312 nM (IC50)

HDAC1

1878 nM (IC50)

HDAC8

3720 nM (IC50)

分子量

511.61

Formula

C28H37N3O6
CAS 号

2411955-43-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ojha R, et al. Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo. Eur J Med Chem. 2020 Mar 15;190:112086.

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