EGFR-IN-52

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-52 

EGFR-IN-52 (Compound 4) 是一种有效的 EGFR 抑制剂，对EGFR 、EGFR L858R-TK 和 EGFR T790M-TK 的 IC50 值分别为 0.358、86.02 和 432.67 µM。EGFR-IN-52 对癌细胞具有毒性，诱导细胞凋亡 (apoptosis)。

EGFR-IN-52

EGFR-IN-52 Chemical Structure

CAS No. : 454436-75-0

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生物活性

EGFR-IN-52 (Compound 4) is a potent EGFR inhibitor with IC50 values of 0.358, 86.02 and 432.67 µM against EGFR, EGFR L858R-TK and EGFR T790M-TK, respectively. EGFR-IN-52 shows cytotoxic activity against cancer cell lines and induces apoptosis[1].

IC50 & Target

EGFR

0.358 μM (IC50)

EGFRL858R

86.02 μM (IC50)

EGFRT790M

432.67 μM (IC50)

分子量

382.44

Formula

C19H18N4O3S
CAS 号

454436-75-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Abbas SY, et al. Synthesis and anticancer activity of thiourea derivatives bearing a benzodioxole moiety with EGFR inhibitory activity, apoptosis assay and molecular docking study. Eur J Med Chem. 2020 Jul 15;198:112363.

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