EGFR-IN-56

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-56 

EGFR-IN-56 (Compound 13a) 是一种有效的 EGFR 抑制剂，对EGFRT790M 和 EGFRT790M/L858R 的 IC50 值分别为 541.7 nM 和 132.1 nM。EGFR-IN-56 在 G2/M 期阻滞癌细胞，诱导细胞凋亡 (apoptosis)。

EGFR-IN-56

EGFR-IN-56 Chemical Structure

CAS No. : 2477726-83-1

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生物活性

EGFR-IN-56 (Compound 13a) is a potent EGFR inhibitor with IC50 values of 541.7 nM and 132.1 nM against EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-56 blocks cancer cells in G2/M phase and induce into late apoptosis[1].

IC50 & Target

EGFRT790M

541.7 nM (IC50)

EGFRL858R/T790M

132.1 nM (IC50)

分子量

434.51

Formula

C23H22N4O3S
CAS 号

2477726-83-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xiao Z, et al. Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors. Bioorg Med Chem. 2020 Oct 1;28(19):115669.

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