Bcl-2-IN-7 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Bcl-2-IN-7

Bcl-2-IN-7 (化合物 6) 是一种有效的 Bcl-2 (b 细胞淋巴瘤 -2) 抑制剂。Bcl-2-IN-7 下调 Bcl-2 的表达，增加 p53、Bax、caspase-7 mRNA 的表达。Bcl-2-IN-7 诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 对 MCF-7、LoVo、HepG2 和 A549 细胞均表现出良好的抗肿瘤活性，其 IC₅₀ 分别为 20.17、22.64、45.57 和 51.50 μM。

Bcl-2-IN-7 Chemical Structure

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生物活性

Bcl-2-IN-7 (compound 6) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC₅₀ values of 20.17, 22.64, 45.57, and 51.50 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively^[1].

IC₅₀ & Target

Bcl-2

Bax

Caspase-7

分子量

510.59

Formula

C₂₄H₂₂N₄O₅S₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Alqahtani AS, et al. Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37(1):86-99.

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