DNA crosslinker 4 dihydrochloride

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DNA crosslinker 4 dihydrochloride 

DNA crosslinker 4 (dihydrochloride) 是一种有效的 DNA 小沟结合剂。DNA crosslinker 4 (dihydrochloride) 对癌细胞 NCI-H460、A2780 和 MCF-7 有一定的抑制活性。DNA crosslinker 4 (dihydrochloride) 可用于抗癌研究。

DNA crosslinker 4 dihydrochloride

DNA crosslinker 4 dihydrochloride Chemical Structure

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生物活性

DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer[1].

IC50 & Target

IC50: 21 ± 1 μM in A2780 cells[1]
体外研究
(In Vitro)

DNA crosslinker 4 (dihydrochloride) (compound 2) (100 μM; 48 h or 96 h) exhibits inhibitory activity against NCI-H460, A2780 and MCF-7[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: NCI-H460, A2780 and MCF-7[1]
Concentration: 100 μM
Incubation Time: 48 h (NCI-H460) and 96 h (A2780 and MCF-7)
Result: Exhibited inhibitory activity against NCI-H460, A2780 and MCF-7 with inhibition percentage of 34%, 59% and 22% at 100 μM; and showed an IC50 value of 21 ± 1 μM in A2780 cells.

分子量

415.32

Formula

C16H24Cl2N8O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Costas-Lago MC, et al. Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity. ACS Med Chem Lett. 2022;13(3):463-469. Published 2022 Feb 10.

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