HSP90-IN-12

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HSP90-IN-12 

在vibsanin A类似物中,vibsanin A类似物C(VAC)对各种癌细胞系表现出抗增殖作用,在vibsanin A类似物中抗增殖活性最强。此外,VAC使细胞中HSP90 相关蛋白的量波动,并抑制HSP90 介导的荧光素酶体外蛋白重折叠。

HSP90-IN-12

HSP90-IN-12 Chemical Structure

CAS No. : 2408643-60-5

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生物活性

Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

分子量

400.55

Formula

C25H36O4

CAS 号

2408643-60-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253.

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