Poly-D-lysine hydrobromide (MW 70000-150000)

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Poly-D-lysine hydrobromide (MW 70000-150000) 

Poly-D-lysine hydrobromide (MW 70000-150000) 是一种人工合成的高分子基质,是神经细胞培养应用最广泛的基质之一。Poly-D-lysine hydrobromide (MW 70000-150000) 可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP,而不影响PrPC

Poly-D-lysine hydrobromide (MW 70000-150000)

Poly-D-lysine hydrobromide (MW 70000-150000) Chemical Structure

CAS No. : 27964-99-4

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生物活性

Poly-D-lysine hydrobromide (MW 70000-150000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 70000-150000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].

体外研究
(In Vitro)

Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1].
The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

70000-150000

Formula

C20H43BrN6O3

CAS 号

27964-99-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229.

    [2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35.

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