Sacituzumab govitecan(Synonyms: IMMU-132)

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Sacituzumab govitecan (Synonyms: IMMU-132)

Sacituzumab govitecan (IMMU-132) 是一种抗体-药物偶联物 (ADC),靶向 Trop-2 传递 SN-38。Sacituzumab govitecan 具有抗癌活性。

Sacituzumab govitecan(Synonyms: IMMU-132)

Sacituzumab govitecan Chemical Structure

CAS No. : 1491917-83-9

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生物活性

Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity[1].

体内研究
(In Vivo)

Sacituzumab govitecan (IMMU-132) (17.5 mg/kg; twice weekly for 4 weeks) results in significant anti-tumor effects in mice bearing human gastric cancer xenografts[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号

1491917-83-9

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31.

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