Envonalkib citrate

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Envonalkib citrate 

Envonalkib citrate 是一种有效和具有口服活性的 ALK 抑制剂，抑制 WT 和突变的 L1196M 和 G1269S-ALK 的 IC50 值分别为 1.96 nM，35.1 nM 和 61.3 nM。Envonalkib citrate 可用于非小细胞肺癌的研究。

Envonalkib citrate

Envonalkib citrate Chemical Structure

CAS No. : 1867204-56-5

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Envonalkib citrate 的其他形式现货产品:

Envonalkib

生物活性

Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer[1].

IC50 & Target

IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1]
体内研究
(In Vivo)

Envonalkib citrate (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

698.52

Formula

C30H34Cl2FN5O9
CAS 号

1867204-56-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Feng G, et, al. Pyridine-substituted 2-aminopyridine protein kinase inhibitors. WO2016015676A1.

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