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Niclosamide monohydrate (Synonyms: 氯硝柳胺一水合物; BAY2353 monohydrate)
Niclosamide monohydrate 是一种 STAT3 抑制剂,在 HeLa 细胞中,IC50 值为 0.25 μM,可以抑制 DNA 复制。
Niclosamide monohydrate Chemical Structure
CAS No. : 73360-56-2
规格 | 价格 | 是否有货 | |
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500 mg | ¥400 | 询问价格 & 货期 |
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Niclosamide monohydrate 的其他形式现货产品:
生物活性 |
Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used for parasitic infections research[1].Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4].Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells[2][3][5]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Niclosamide monohydrate (0.6 nM-46 µM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells[3].Niclosamide monohydrate (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells [4].Niclosamide monohydrate (10 μM) treatment inhibits virus replication in Vero E6 cells[5]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[3]
Cell Viability Assay[4]
Cell Viability Assay[5]
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体内研究 (In Vivo) |
Niclosamide monohydrate (Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
345.13 |
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Formula |
C13H10Cl2N2O5 |
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CAS 号 |
73360-56-2 |
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中文名称 |
氯硝柳胺一水合物 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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