Citric acid trilithium salt tetrahydrate(Synonyms: 柠檬酸三锂盐四水合物; Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Citric acid trilithium salt tetrahydrate (Synonyms: 柠檬酸三锂盐四水合物; Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate) 纯度: ≥98.0%

Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是藤黄果的主要活性成分。Citric acid trilithium salt tetrahydrate 可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ，并具有减肥效果。Citric acid trilithium salt tetrahydrate 有效抑制结石形成并抑制 HIF，具有抗氧化，抗炎和抗肿瘤作用。

Citric acid trilithium salt tetrahydrate(Synonyms: 柠檬酸三锂盐四水合物; Lithium citrate tribasic tetrahydrate; Trilithium citrate tetrahydrate)

Citric acid trilithium salt tetrahydrate Chemical Structure

CAS No. : 6080-58-6

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in Water ￥550 In-stock
100 mg ￥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Citric acid trilithium salt tetrahydrate 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Drug Repurposing Compound Library
  • Antibacterial Compound Library
  • Anti-COVID-19 Compound Library
  • Medicine Food Homology Compound Library
  • Orally Active Compound Library
  • FDA Approved & Pharmacopeial Drug Library
  • Microbial Metabolite Library

生物活性

Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) is the major active ingredient of Garcinia cambogia. Citric acid trilithium salt tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Citric acid trilithium salt tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

体外研究
(In Vitro)

Citric acid trilithium salt tetrahydrate shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Citric acid trilithium salt tetrahydrate can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Citric acid trilithium salt tetrahydrate suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].
In chicken hepatocytes, Citric acid trilithium salt tetrahydrate decreases the accumulation of lipid droplets and accelerated energy metabolism. Citric acid trilithium salt tetrahydrate protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Citric acid (100-200 mg/kg) trilithium salt tetrahydrate treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Citric acid trilithium salt tetrahydrate. Citric acid trilithium salt tetrahydrate attenuates the oxidative stress induced by calcium oxalate crystallization. Citric acid trilithium salt tetrahydrate has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Citric acid trilithium salt tetrahydrate alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1].
The administration of Citric acid trilithium salt tetrahydrate can suppress body weight gain and fat accumulation in animals[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

281.98

Formula

C6H13Li3O11
CAS 号

6080-58-6
中文名称

柠檬酸三锂盐四水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : ≥ 100 mg/mL (354.64 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5464 mL 17.7318 mL 35.4635 mL
5 mM 0.7093 mL 3.5464 mL 7.0927 mL
10 mM 0.3546 mL 1.7732 mL 3.5464 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Liu X, et al. Hydroxycitric acid inhibits renal calcium oxalate deposition by reducing oxidative stress and inflammation. Curr Mol Med. 2020 Jan 3.

    [2]. Ibuki M, et al. Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration. Int J Mol Sci. 2019 Oct 11;20(20). pii: E5049.

    [3]. Han S, et al. Hydroxycitric Acid Tripotassium Inhibits Calcium Oxalate Crystal Formation in the Drosophila Melanogaster Model of Hyperoxaluria. Med Sci Monit. 2019 May 17;25:3662-3667.

    [4]. Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务