Topotecan hydrochloride hydrate(Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

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Topotecan hydrochloride hydrate (Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

Topotecan hydrochloride hydrate 是一种口服有效的拓扑异构酶 I (Topoisomerase I) 抑制剂。Topotecan hydrochloride hydrate 诱导细胞周期阻滞在 G0/G1 和 S 期，促进凋亡 (apoptosis)。Topotecan hydrochloride hydrate 具有抗癌活性。

Topotecan hydrochloride hydrate(Synonyms: SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate)

Topotecan hydrochloride hydrate Chemical Structure

CAS No. : 1044663-62-8

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Topotecan hydrochloride hydrate 的其他形式现货产品:

Topotecan Hydrochloride

生物活性

Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

IC50 & Target

Topoisomerase I

 

体外研究
(In Vitro)

Topotecan hydrochloride hydrate obviously inhibits proliferation of human glioma cells and glioma stem cells (GSCs) in a dose- and time-dependent manner[1].
Topotecan hydrochloride hydrate (0-40 μM) obviously inhibits the cell viability compared with the control groups, in a dose-dependent manner[1].
Topotecan hydrochloride hydrate shows anti-proliferation activity against U251, U87, GSCs-U251 and GSCs-U87 cells, with IC50 values of 2.73±0.25, 2.95±0.23, 5.46±0.41, and 5.95±0.24 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Topotecan hydrochloride hydrate (0.5, 1.0, and 1.5 mg/kg; Orally, daily) causes greater reduction in microvascular density in an ovarian cancer model, but the mice treated with 1.5 mg/kg daily, oral Topotecan show decreased food intake, and a lesser antitumor effect[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

475.92

Formula

C23H26ClN3O6
CAS 号

1044663-62-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang FL, et al. PLoS One. 2013 Nov 26;8(11):e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells.

    [2]. Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17(17):5656-67.

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