Fmoc-4,5-脱氢-D-亮氨酸

Fmoc-4,5-脱氢-D-亮氨酸是一种Fmoc保护的亮氨酸衍生物，可能对蛋白质组学研究和固相肽合成技术有用。亮氨酸是较简单的氨基酸之一-异丁基作为侧链。当掺入多肽链时，该较小的侧链赋予高度的柔性，并赋予中等的疏水作用。通常用诸如吡啶之类的碱除去Fmoc基团-这是酸性labile Boc基团的正交脱保护策略。

Fmoc-4,5-dehydro-D-Leucine is an Fmoc protected leucine derivative that is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Leucine is one of the more simple amino acids – an isobutyl group as the side chain. This smaller side chain confers a high degree of flexibility, and imparts a moderate hydrophobic effect when incorporated into a polypeptide chain. The Fmoc group is typically removed with a base such as pyridine – an orthogonal de-protection strategy to the acid labilie Boc group.