Isobavachalcone(Synonyms: 补骨脂乙素; Corylifolinin; Isobacachalcone)

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Isobavachalcone (Synonyms: 补骨脂乙素; Corylifolinin; Isobacachalcone) 纯度: 99.01%

Isobavachalcone (Corylifolinin) 来源于补骨脂，是一种 Akt 信号通路的有效抑制剂，可诱导人类癌细胞凋亡 (以 IC50 值为 7.92 μM 抑制 OVCAR-8 癌细胞生长)，具有抗癌和抗增殖活性。Isobavachalcone 还能诱导 OVCAR-8 细胞中活性氧的产生。

Isobavachalcone(Synonyms: 补骨脂乙素; Corylifolinin; Isobacachalcone)

Isobavachalcone Chemical Structure

CAS No. : 20784-50-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥924 In-stock
5 mg ￥840 In-stock
10 mg ￥1450 In-stock
25 mg ￥2900 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].

IC50 & Target

IC50: 7.92 μM (OVCAR-8 cell)[1]
体外研究
(In Vitro)

Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively[1].
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation[1].
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells
Concentration: 6.0-48.0 μM
Incubation Time: 72 hours
Result: Inhibited the proliferation of human cancer cells.

Western Blot Analysis[1]

Cell Line: OVCAR-8 or PC3 cells
Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
Incubation Time: 6 hours
Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: OVCAR-8 cells and PC3 cells
Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
Incubation Time: 72 hours
Result: Led to dose dependent increase of apoptosis.

体内研究
(In Vivo)

Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g)[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours
Result: Increased in blood glucose levels.

分子量

324.37

Formula

C20H20O4
CAS 号

20784-50-3
中文名称

补骨脂乙素；补骨酯乙素；异补骨脂查耳酮；异补骨脂查尔酮
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 11 mg/mL (33.91 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Jing H, et al. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett. 2010 Aug 28;294(2):167-77.

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