上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
FB23 纯度: 99.49%
FB23 是一种有效的,选择性的 FTO 去甲基化酶抑制剂,IC50 为 60 nM。FB23 直接与 FTO 结合并选择性抑制 FTO 的 mRNA N6-甲基腺嘌呤脱甲基酶活性。
FB23 Chemical Structure
CAS No. : 2243736-35-6
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1320 | In-stock | |
5 mg | ¥1200 | In-stock | |
10 mg | ¥2200 | In-stock | |
25 mg | ¥4500 | In-stock | |
50 mg | ¥7000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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FB23 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Targeted Diversity Library
生物活性 |
FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO‘s mRNA N6-methyladenosine (m6A) demethylase activity[1]. |
IC50 & Target |
IC50: 60 nM (FTO)[1] |
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体外研究 (In Vitro) |
FB23 (72 hours) treatment inhibits acute myeloid leukemia (AML) cells proliferation with IC50 values of 44.8 μM, 23.6 μM for NB4 and MONOMAC6 AML cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The Cmax and Tmax value of FB23 are 142.5 ng/mL and 0.4 hr, respectively[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
377.22 |
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Formula |
C18H14Cl2N2O3 |
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CAS 号 |
2243736-35-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 125 mg/mL (331.37 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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