多球壳菌素
基本信息
| 产品名称 | 多球壳菌素 |
|---|---|
| 英文名称 | Myriocin |
| 别名 | Myriocin;ISP-1 |
| 英文别名 | (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin |
| 应用 | An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. |
| 规格或纯度 | 98% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been sμggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.Highly potent serine palmitoyltransferase inhibitor (K i = 0.28 nM). Shows 10 times the immunosuppressant potency of cyclosporine . Depletes cellular sphingolipids and induces apoptosis. Inhibits proliferation (IC 50 = 15 nM, CTLL-1 |
一般描述
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.
An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
相关属性
| CAS编号 | 35891-70-4 |
|---|---|
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water. |
| 储存温度 | -20°C储存 |
| RTECS | JX3890000 |
| MDL号 | MFCD01632772 |
| 密度 | 1.123 |
| 分子量 | 401.54 |
| 分子式 | C21H39NO6 |
| 品牌 | Jinpan |
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| PubChem CID | 6438394 |