伊曲康唑
基本信息
| 产品名称 | 伊曲康唑 |
|---|---|
| 英文名称 | Itraconazole |
| 别名 | 伊曲康唑；4-[4-[4-[4-[[2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮；斯皮仁诺；依他康唑；亚特那唑；奥立康唑；孢粉； R51211 |
| 英文别名 | Oriconazole;R51211;Sporanox;2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one |
| 规格或纯度 | 2mM in DMSO |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | 细胞色素p450 CYP3A4抑制剂（咪达唑仑羟基化的IC 50 = 16-26 nM）。对真菌酶的亲和力高于哺乳动物细胞色素p450。穿越血脑屏障的能力有限。抗真菌活性。 |
一般描述
Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.
Itraconazole is a triazole antifungal agent. It inhibits the fungal CYP(cytochrome P450) oxidase-mediated synthesis of ergosterol. Itraconazole also acts as an effective hedgehog signaling inhibitor in a Ptch-independent manner, presumably by binding smoothened (Smo) at a site distinct from that targeted by cyclopamine and SAG. Itraconazole is an inhibitor of CYP3A4.
A traizole antifungal agent
相关属性
| CAS编号 | 84625-61-6 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 167.0 to 171.0 °C |
| 储存温度 | -80℃储存 |
| Reaxys-RN | 6042047 |
| RTECS | XZ5481000 |
| 分子量 | 705.63 |
| 分子式 | C35H38Cl2N8O4 |
| 品牌 | Jinpan |
| PubChem CID | 3793 |