二甲胺四环素盐酸盐
抗生素。展示多种效果。
2mM in Water
有货
基本信息
| 产品名称 | 二甲胺四环素盐酸盐 |
|---|---|
| 英文名称 | Minocycline hydrochloride |
| 别名 | 盐酸米诺环素,盐酸二甲胺四环素 |
| 英文别名 | [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide |
| 规格或纯度 | 2mM in Water |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects. Minocycline acts as a matrix metalloproteinase (MMP) inhibitor; attenuates disease severity in mouse models of multiple sclerosis. Minocycline also inhibit the enzymatic activity of poly(ADP-ribose) polymerase-1 (PARP-1) and angiogenesis. In addition, Minocycline is suggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV. Orally active and brain penetrant.Antibiotic. Demonstrates anti-inflammatory, antiapoptotic, antioxidant and neuroprotective effects. Blood-brain barrier permeable. Matrix metalloproteinase (MMP) inhibitor (IC 50 = 290 μM at stromelysin (MMP-3). |
一般描述
溶于水，遇光不稳定，味苦。
Minocycline hydrochloride has been used: · to prepare nanoliposomes to check its effect on macrophages · for the inhibition of neuroinflammation and neuropathic pain · to treat glioma in murine GL261 glioma cells
相关属性
| CAS编号 | 13614-98-7 |
|---|---|
| 敏感性 | 对热敏感 |
| 比旋光度 | -170 to -180 deg(C=0.5、0.1mol/L HCl) |
| 熔点 | 205-210℃ |
| 沸点 | 813℃ |
| 储存温度 | -80℃储存 |
| Reaxys-RN | 4836328 |
| RTECS | QI7630500 |
| 分子量 | 493.94 |
| 分子式 | C23H27N3O7.HCl |
| EC号 | 237-099-7 |
| 品牌 | Jinpan |
| PubChem CID | 54685925 |