板霉素

板霉素是由链霉菌|菌株产生的新型广谱革兰氏阳性抗生素。可以认为，板霉素可以通过选择性地抑制脂肪酸合成途径的延长酶β-酮酰基酰基载体蛋白合酶FabF来抑制细菌的生长。结合研究表明，酰基-FabF中间体复合物的形成诱导了platfsimycin相互作用所必需的fabf构象变化。板霉素可以有效杀死大量的金黄色葡萄球菌，粪便肠球菌和肺炎链球菌，包括对奥沙西林和万古霉素有抗药性的菌株。板霉素对白念珠菌不显示抗真菌活性或对哺乳动物HeLa培养物没有毒性，并且对治疗有效。小鼠体内的金黄色葡萄球菌感染。板霉素对野生型|

Platensimycin is a novel broad spectrum gram-positive antibiotic produced by strains of|Streptomyces platensis|. Platensimycin is believed to inhibit bacterial growth by selectively inhibiting the elongation enzyme, β-ketoacyl acyl carrier protein synthase FabF of the fatty acid synthesis pathway. Binding studies indicate that acyl-FabF intermediate complex formation induces a FabF conformation change that is necessary for the interaction of Platensimycin. Platensimycin effectively kills numerous|Staphylococcus aureus|,|Enterococcus faecium|, and|Streptococcus pneumoniae|strains, including the ones that are resistant to oxacillin and vancomycin . Platensimycin does not exhibit antifungal activity towards|Candida albicans|or toxicity toward mammalian HeLa culture and is efficacious in treating|S. aureus|infection in mice|in vivo|. Although Platensimycin is ineffective toward wild-type|E. coli|due to the presence of functional multidrug efflux pump, Platensimycin does inhibit the growth of efflux-negative|E. coli|strains. Platensimycin is an inhibitor of Fatty Acid Synthase.