哌环素
半合成四环素
有货
基本信息
| 产品名称 | 哌环素 |
|---|---|
| 英文名称 | Pipacycline |
| 英文别名 | Mepicycline |
| 运输条件 | 超低温冰袋运输 |
一般描述
哌帕环素（匹哌环素）是半合成的四环素，由甲醛和4-羟乙基哌嗪与四环素的曼尼希缩合反应形成。引入哌嗪可提高生物利用度，但曼尼希碱是前药，可转变回母体化合物。哌帕环素与青霉素V一起以盐形式用于肠胃外用途（青哌环素）。四环素分子酰胺区的固有体外活性和SAR尚未广泛研究。
Pipacycline (mepicycline) is a semi-synthetic tetracycline formed by a Mannich condensation of formaldehyde and 4-hydroxyethylpiperazine with tetracycline. The introduction of the piperazine improves bioavailability, but Mannich bases are pro- drugs, converting back to the parent compound. Pipacycline is used commercially as a salt in combination with penicillin V for parenteral use (penimepicycline). The intrinsic in vitro activity and SARs for the amide region of the tetracycline molecule have not investigated extensively.
相关属性
| CAS编号 | 1110-80-1 |
|---|---|
| 折光率 | n20D1.72 (Predicted) |
| 沸点 | ~895.8° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in ethanol, methanol, DMSO, DMF, and water. |
| 储存温度 | -20°C储存 |
| 密度 | ~1.6 g/cm3(Predicted) |
| 分子量 | 586.63 |
| 分子式 | C₂₉H₃₈N₄O₉ |
| EC号 | 214-176-3 |
| 品牌 | Jinpan |
| Smiles | C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@H]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCN5CCN(CC5)CCO)N(C)C)O |
| PubChem CID | 54686184 |