余氯霉素

抗坏血酸是从真菌中分离出的异戊烯基苯酚天然产物，通过抑制MMP-9基因的活化来阻断MMP-9（基质金属蛋白酶9）的表达。基质金属蛋白酶与侵袭和转移细胞的行为有关，因为这些蛋白质负责细胞外基质的修饰和降解。已显示Ascochlorin会阻止Fra-1蛋白上核转录因子AP-1（激活蛋白-1）的激活，从而导致下游MMP-9基因表达的抑制。利用该活性来对抗MX-1细胞（雌激素受体阴性癌细胞）的生长，其中在缺乏雌激素受体化疗靶点的情况下，阿斯科霉素对AP-1的阻断提供了至关重要的细胞毒性作用。还已经观察到抗草霉素与

Ascochlorin is a prenylphenol natural product isolated from the|Ascochyta viciae|fungus that blocks the expression of MMP-9 (matrix metalloproteinase-9) by suppressing activation of the MMP-9 gene. Matrix metalloproteinases are implicated in the behavior of invading and metastatic cells, as these proteins are responsible for modification and degradation of the extracellular matrix. Ascochlorin is shown to blockade the activation of nuclear transcription factor AP-1 (activator protein-1) on the Fra-1 protein, which leads to a suppression of MMP-9 gene expression downstream. This activity is exploited against the growth of MX-1 cells (estrogen receptor-negative cancer cells), where blockade of AP-1 by Ascochlorin provides a crucial cytotoxic handle in the absence of the estrogen receptor chemotherapeutic target. Ascochlorin has also been observed to bind nuclear hormone receptors, and a library of Ascochlorin derivatives showed activity as peroxisome proliferator activated receptor gamma (PPARγ) agonists. Ascochlorin is an activator of p53.