伯那霉素A

伯尼霉素A是硫肽抗生素家族的成员，该家族被描述为含有硫和高度修饰的环肽。据报道该化合物诱导了tipA基因，该基因产生了属于转录调节子MerR家族的蛋白质TipAL和TipsAS。研究表明，贝尼霉素A是贝尼霉素的主要成分。伯尼霉素被认为会影响核糖体A位点的功能，在革兰氏阳性细菌中作为蛋白质合成的有力抑制剂，并且具有与硫链霉菌素相同的作用方式。研究报告称，贝尼霉素A是从链霉菌中分离出来的，并在结构上与磺霉素I有关。其他贝尼霉素包括贝尼霉素B，C和D。

Berninamycin A is a member of the thiopeptide antibiotic family, which is described to contain sulfur and highly modified cyclic peptides. The compound has been reported to induce the tipA gene, which produces the proteins TipAL and TipsAS, that belong to the MerR family of transcription regulators. Studies indicate that Berninamycin A is a major component of Berninamycin. Berninamycin is described to affect the function of the ribosomal A site, act as a vigorous inhibitor of protein synthesis in gram-positive bacteria, and has the same mode of action as Thiostrepton . Studies report that Berninamycin A is isolated from|Streptomyces|and is structurally related to sulfomycin I. Other Berninamycins include Berninamycin B, C, and D .